The higher intake of foods rich in purines (e.g., liver, kidney, sardines) contributes to hyperuricemia or gout, or a strict diet low-purine, lowering urate levels in plasma of about 60 mmol / L (1 mg / dL).

Urati precipitate as needle-shaped crystals of monosodium urate, which can accumulate in the extracellular tissue without vessels (eg, cartilage), in poorly vascularized tissue (eg. Tendons, tendon sheath, ligaments, the stock market) and around the cooler, the distal joints and tissues (eg. Ear ). In the long-term, severe hyperuricemia, urate crystals invest in larger central joints in parenchymal organs, for example, the kidneys. The acidic pH of urine urate easily toppling the form of small plate or irregular crystals who have a way to aggregate to form sand or stones with the risk of obstruction. Tofi are monosodium urate crystal deposits that occur mainly in and around the joints and in the skin.

What disease is higher and it lasts longer, the greater the likelihood and severity of symptoms. Urate levels may be elevated due to reduced excretion, increased production or increased intake of purine. It is not clear why only some people hiperuricemične suffer from gout.